This paper uses land use data to analyze Guangzhou's temporal-spatial evolution in landscape pattern from 1995 to 2015, and employs geographic detector to discuss the influence of spatial factor on landscape pattern, aiming at providing revelation for allocating land resources. Guangzhou's construction land has largely increased, while other landscape areas have declined, with farmland, woods, waters, grass land, and unused land at a decreasing order. Transformation occurs frequently among farmland, woods, waters and construction land in landscape pattern, most concentrating in Huadu, Baiyun, Huangpu, Fanyu and southwestern Zengcheng. The changes are in reverse proportion to level, slope, distance to subway and major roads, and in an upside-down U shape to urban downtown. Woods, farmland and construction land changes are mainly subject to the distance to subway; grassland change is subject to level and slope; unused land change is subject to the distance to major roads. Landscape pattern changes happen more easily in two factors' interaction than one single factor.